Introduction to Cannabis and Its Derivatives

Cannabis, a plant species scientifically known as Cannabis sativa, is the source of various products that contain approximately 540 distinct chemical substances [1].

Marijuana, a term often used interchangeably with cannabis, specifically refers to parts or products derived from the Cannabis sativa plant that contain significant amounts of tetrahydrocannabinol (THC) [1].

Understanding Cannabinoids

Cannabinoids are a group of active compounds found in the cannabis plant. They are primarily classified into three categories:

  1. Phytocannabinoids: These are cannabinoids present in the leaves, flowers, stems, and seeds of the Cannabis sativa plant [4].

  2. Endogenous cannabinoids: Also known as endocannabinoids, these compounds are naturally produced by the human body. Examples include anandamide (AE) and 2-arachidonoylglycerol (2-AG) [4].

  3. Synthetic cannabinoids: These are artificially created compounds that mimic the effects of natural cannabinoids.

The Role of THC and CBD

THC is the primary psychoactive compound in cannabis, responsible for the plant's mind-altering effects. It has been extensively studied for its potential therapeutic benefits, but its psychoactive properties and potential for abuse limit its usefulness [7].

Cannabidiol (CBD), another prominent cannabinoid, does not produce a "high" and is considered non-impairing [6]. CBD has gained popularity for its potential health benefits, and research continues to explore its possible therapeutic applications.

Medical uses of THC

Medical Uses of Cannabis and Cannabinoids

Cannabis and cannabinoids have been used for various medicinal purposes, including managing symptoms such as anxiety, loss of appetite, nausea, pain, and sleep disturbance in cancer patients [10].

Medical marijuana usage is typically considered safe, but the varying THC content in different strains can complicate dosing [9].

Potential Side Effects of Medical Marijuana

Some common side effects of medical marijuana use include:

Other possible side effects may include nausea, vomiting, disorientation, and hallucinations [9].

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Cannabis Hyperemesis Syndrome

Cannabis hyperemesis syndrome (CHS) is a condition caused by long-term cannabis use.

CHS is characterized by recurring episodes of nausea, vomiting, dehydration, and abdominal pain, often leading to frequent visits to the emergency department [1].

The term "hyperemesis" means severe vomiting, and another name for CHS is cannabinoid hyperemesis syndrome [1].

This rare condition typically affects long-term, daily marijuana users and is associated with THC and related chemicals found in cannabis [2].

Symptoms of Cannabis Hyperemesis Syndrome

Common symptoms of CHS include:

  • Persistent vomiting and nausea
  • Abdominal pain or cramping
  • Morning sickness
  • Dehydration
  • Loss of appetite
  • Weight loss [4]

Medication THC

Treatment and Management of CHS

The most effective treatment for CHS is to stop using cannabis completely [9].

For those who are unwilling or unable to cease cannabis use, some short-term relief options are available, though CHS is likely to continue recurring until cannabis use is stopped.


Anti-emetic medications are commonly prescribed to alleviate nausea and vomiting [9].

Hot Bath THC

Hot Water Bathing

Many patients with CHS find temporary relief from their symptoms by taking hot showers or baths [7].

Lifestyle Changes

Adopting a healthier lifestyle, including proper hydration, a balanced diet, and stress management, can help manage CHS symptoms and promote overall well-being [10].


Cannabis hyperemesis syndrome is a rare but serious condition affecting long-term cannabis users. The most effective treatment is to stop using cannabis.

For those who continue to use cannabis, some short-term relief options are available, but the condition is likely to persist until cannabis use is discontinued.

It is essential to consult a healthcare professional if you suspect you or someone you know is experiencing CHS.

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More Articles here:

The Ultimate Guide to Storing Cannabis

Unlocking the Health benefits of Cannabis

CHS Symptoms and treatment. Cannabis Hyperemesis Syndrome

Medical Cannabis and Potential for Widespread Adoption

Navigating Cannabis Use and the Fentanyl Threat

Medical Marijuana Therapeutic uses

Top Benefits of Cannabis for Men's Health here.

The Secret to Keeping your Cannabis Potent and Flavorful.

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DISCLAIMER: The information provided in this article is for informational purposes only and should not be construed as medical, financial, or legal advice. The use of cannabis and its derivatives may have risks and potential side effects, and individuals should always consult with a qualified healthcare professional before using cannabis or any other substances for medicinal purposes. This article does not endorse the use of cannabis or any other substances for recreational purposes. The author and publisher of this article are not responsible for any damages or losses that may result from the use of the information presented herein. Readers are advised to do their own research and exercise caution when making decisions related to cannabis or any other substances.

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